TY  - GEN
T1  - Spontaneous neoplasia in the western clawed frog Xenopus tropicalis
AU  - Suzuki, Makoto
AU  - Igawa, Takeshi
AU  - Suzuki, Nanoka
AU  - Ogino, Hajime
AU  - Ochi, Haruki
DO  - 10.17912/micropub.biology.000294
UR  - http://beta.micropublication.org/journals/biology/micropub-biology-000294/
AB  - Xenopus tropicalis is an excellent model organism for studies on vertebrate development and regeneration (Horb et al., 2019) and is also useful for the study of tumor formation (Van Nieuwenhuysen et al., 2015; Naert et al., 2016). Spontaneously occurring neoplasia in amphibians have been reported, such as in X. laevis, Rana pipiens, and Andria japonicus (McKinnell et al., 1968; Meyer-Rochow et al., 1991; Kawasumi et al., 2012). In X. laevis, one of 4,000 frogs (a 2.5–3-year-old female), which were maintained in artificial outdoor ponds, displayed renal adenocarcinoma without other developmental disorders, indicating that the tumor formation was quite rare in X. laevis (Meyer-Rochow et al., 1991). In contrast to X. laevis, 3.66 % of R. pipiens in the wild heterogeneous populations had renal adenocarcinoma (McKinnell et al., 1968), which was experimentally induced by herpesvirus (Granoff, 1973). Currently, there are no reports of spontaneous neoplasia in X. tropicalis, although recently developed genome editing technologies such as TALEN and CRISPR/Cas9 offer opportunities to induce neoplasia by simple disruption of tumor suppressor genes (Van Nieuwenhuysen et al., 2015; Naert et al., 2016), which would allow modeling of human cancer in this species. The spontaneously occurring neoplasia in X. tropicalis could provide excellent opportunities to understand how the genetic background of this species influences the neoplasia phenotypes in combination with disruption experiments of tumor suppressor genes.
PY  - 2020
JO  - microPublication Biology
ER  -