TY  - GEN
T1  - Evidence of slightly increased Pol II pausing in UPF1-depleted Drosophila melanogaster cells
AU  - Singh, Anand K
AU  - Zhang, Jie
AU  - Hebenstreit, Daniel
AU  - Brogna, Saverio
DO  - 10.17912/micropub.biology.000319
UR  - http://beta.micropublication.org/journals/biology/micropub-biology-000319/
AB  - UPF1 is an RNA helicase that scans RNA to unwind secondary structures and to displace associated factors (Franks et al., 2010; Fiorini et al., 2015; Lee et al., 2015; Kanaan et al., 2018). UPF1 has been mostly studied for its role in nonsense mediated mRNA decay (NMD) and other translation-dependent RNA quality-control pathways in the cytoplasm (Isken and Maquat, 2008; Kim and Maquat, 2019). However, we have recently reported that UPF1 associates, genome wide, with nascent transcripts at most Pol II transcription sites in Drosophila (Singh et al., 2019). The association of UPF1 with nascent transcripts appears to be necessary for the release of processed polyadenylated mRNAs from their transcription sites and also for their export from nucleus to cytoplasm (Singh et al., 2019).
PY  - 2020
JO  - microPublication Biology
ER  -