TY  - GEN
T1  - Caenorhabditis elegans larvae undergo early developmental arrest on a diet of Gram-positive bacterium Enterococcus faecalis
AU  - Dasgupta, Madhumanti
AU  - Bojanala, Nagagireesh
AU  - Shashikanth, Meghana
AU  - Singh, Varsha
DO  - 10.17912/micropub.biology.000321
UR  - http://beta.micropublication.org/journals/biology/micropub-biology-000321/
AB  - Caenorhabditis elegans feeds on bacteria in decomposing vegetation. Lipids, carbohydrates and proteins derived from microbes are digested into fatty acids, simple sugars and amino acids in C. elegans alimentary canal and absorbed by intestinal cells containing microvilli. Approximately 80% of fatty acids in C. elegans is derived from E. coli (Perez and Van Gilst, 2008). Nutrient limiting conditions can cause developmental delay in larvae (Cassada and Russell, 1975; Golden and Riddle, 1982) while complete starvation leads to L1 larval arrest or dauer formation (Baugh, 2013). Interestingly it has been reported that C. elegans fed on yeast Cryptococcus curvatus show developmental lag (Sanghvi et al., 2016) and growth arrest on Gram-positive bacterium Enterococcus faecalis (Garsin et al., 2001). We have recently shown that E. faecalis infection causes lipid droplet utilization in adult C. elegans, a process termed immunometabolism (Dasgupta et al., 2020). In this study, we have investigated the developmental arrest induced by E. faecalis in C. elegans larvae to show that the arrest is induced at L1 and L2 larva stage.
PY  - 2020
JO  - microPublication Biology
ER  -