TY  - GEN
T1  - A mutation that alters the 255th glutamate to lysine in RSKS-1/S6 kinase reliably extends the lifespan of C. elegans
AU  - Lee, Jongsun
AU  - Kim, Sieun S.
AU  - Lee, Seung-Jae V.
DO  - 10.17912/micropub.biology.000322
UR  - http://beta.micropublication.org/journals/biology/micropub-biology-000322/
AB  - Mechanistic target of rapamycin (mTOR), a serine/threonine protein kinase, regulates biological processes in response to changes in nutrients or metabolites (Reviewed in Liu and Sabatini, 2020). Inhibition of mTOR signaling delays aging and increases lifespan in multiple organisms by downregulating substrates, including S6 kinase (S6K) that phosphorylates ribosomal subunit 6 (Reviewed in Kennedy and Lamming, 2016). Genetic inhibition of RSKS-1, the Caenorhabditis elegans S6 kinase, extends lifespan via decreasing protein synthesis and upregulating longevity-promoting factors (Reviewed in Johnson et al., 2013; Lee et al. 2015). However, the longevity phenotypes of previously characterized loss-of-function rsks-1 mutants are variable and greatly affected by environmental factors, such as temperatures (Seo et al., 2013; Miller et al., 2017). Here, we aimed at identifying rsks-1 mutants whose lifespan phenotypes are robust and reproducible at 20°C, the standard temperature for C. elegans lifespan assays.
PY  - 2020
JO  - microPublication Biology
ER  -