TY  - GEN
T1  - lin-41 controls dauer formation and morphology via lin-29 in C. elegans
AU  - Cale, Allison R
AU  - Karp, Xantha
DO  - 10.17912/micropub.biology.000323
UR  - http://beta.micropublication.org/journals/biology/micropub-biology-000323/
AB  - In response to adverse environments C. elegans larvae may form stress-resistant and developmentally arrested dauer larvae. Entry into dauer interrupts developmental progression after the second larval molt (Cassada and Russell 1975), and the dauer formation decision must be coordinated with developmental pathways. Heterochronic genes control stage-specific cell fate decisions, and these genes interconnect with the dauer formation (daf) pathway in several ways. Dauer formation and daf genes affect heterochronic phenotypes, and conversely, heterochronic genes can impact dauer by controlling the timing of dauer formation, the morphology of dauer larvae, or the ability to enter dauer (Liu and Ambros 1989; Liu and Ambros 1991; Antebi et al. 1998; Tennessen et al. 2010; Karp and Ambros 2011; Karp and Ambros 2012). Here we find that the lin-41 heterochronic gene regulates the dauer formation decision and dauer morphogenesis via its canonical target, lin-29.
PY  - 2020
JO  - microPublication Biology
ER  -