TY  - GEN
T1  - Neuronal expression of Ca2+ oscillation initiator is linked to rapid neonatal growth in mice
AU  - Kang, Woojin
AU  - Yamatoya, Kenji
AU  - Miyado, Kenji
AU  - Miyado, Mami
AU  - Miyamoto, Yoshitaka
DO  - 10.17912/micropub.biology.000325
UR  - http://beta.micropublication.org/journals/biology/micropub-biology-000325/
AB  - Repetitive increases in the cytoplasmic calcium concentration (Ca2+ oscillation) control a wide variety of biological events (Dupont et al. 2011). In fertilization, a sperm-bearing factor, phospholipase C zeta 1 (PLCz1), triggers Ca2+ oscillation and resumes cell division in eggs. Citrate synthase (CS) is localized to the mitochondrial matrix, where it catalyzes a reaction between acetyl-coenzyme A (CoA) and oxaloacetate to form citric acid (Surpin and Chory 1997) (Figure 1A). The extra-mitochondrial form of CS (eCS) is encoded by a separate gene in mice and is expressed by alternative splicing from the CS gene in humans (Kang et al. 2020). eCS functions as a secondary factor triggering Ca2+ oscillation, which is transferred from the sperm to the eggs (Kang et al. 2020). More specifically, eCS has been found to trigger an initial Ca2+ spike using a PLCz1-independent mechanism. However, the role of eCS-triggered Ca2+ oscillation in broad cell functions is unknown.
PY  - 2020
JO  - microPublication Biology
ER  -