TY  - GEN
T1  - Piwi in the stem cell niche regulates nurse cell number and oocyte specification
AU  - Zhu, Gina
AU  - Gonzalez, Lauren E
AU  - Lin, Haifan
DO  - 10.17912/micropub.biology.000327
UR  - http://beta.micropublication.org/journals/biology/micropub-biology-000327/
AB  - In the Drosophila ovary, the proliferation of germline cells and differentiation of the oocyte is informed by cues from a variety of ovarian somatic cell (OSC) types. In particular, the stem cell niche, composed of cap cells, terminal filament cells, and escort cells, directly signals to germline stem cells (GSCs) to promote their self-renewal and differentiation into cystoblasts. Cap cells express Decapentaplegic (Dpp), which signals to the germline to promote proliferation and maintenance of GSCs (Xie and Spradling 1998, Chen and McKearin 2003, Song et al. 2004). Subsequently, the differentiation of cystoblasts and their four synchronous divisions with incomplete cytokinesis to form 16-cell cysts depends on the repression of Dpp by Wnt, EGF, and Hedgehog signaling from escort cells (Liu et al. 2010, Luo et al. 2015, Mottier-Pavie et al. 2016, Huang et al. 2017). The germline cyst then becomes encased in somatic follicle cells to form an egg chamber, in which one germline cell is the oocyte and the other 15 are polyploid nurse cells. Follicle cells impact multiple aspects of germline differentiation throughout the rest of oogenesis, including polarization of the oocyte guided by JAK/STAT and Notch signaling (reviewed in Riechmann and Ephrussi 2001).
PY  - 2020
JO  - microPublication Biology
ER  -