TY  - GEN
T1  - Individual point mutations in two ERAD E2 ubiquitin-conjugating enzymes do not affect Caenorhabditis elegans spontaneous reversal frequency
AU  - Oswald, Mackenzi
AU  - Hulsey-Vincent, Heino
AU  - Dahlberg, Caroline (Lina)
DO  - 10.17912/micropub.biology.000328
UR  - http://beta.micropublication.org/journals/biology/micropub-biology-000328/
AB  - Maintaining proteostasis, or protein homeostasis, is an important cellular function because misfolded proteins can aggregate and contribute to neurodegenerative diseases. One way that cells preserve proteostasis is through the Endoplasmic Reticulum Associated Degradation pathway (ERAD). ERAD relies on interactions between E2 ubiquitin-conjugating enzymes and E3 ubiquitin ligases to ubiquitylate misfolded proteins in order to signal for their destruction via the proteasome (Vembar and Brodsky 2008). We investigated if missense mutations in genes that encode two E2 ubiquitin-conjugating enzymes in C. elegans, UBC-6 and UBC-7, affect spontaneous reversal frequency (Brockie et al. 2001; Jones et al. 2002; Stewart et al. 2016; Zheng et al. 1999).
PY  - 2020
JO  - microPublication Biology
ER  -