TY - GEN T1 - The ubiquitylome of developing cortical neurons AU - Menon, Shalini AU - Goldfarb, Dennis AU - Cousins, Emily M. AU - Major, M. Ben AU - Gupton, Stephanie L. DO - 10.17912/micropub.biology.000333 UR - http://beta.micropublication.org/journals/biology/micropub-biology-000333/ AB - Ubiquitylation is a posttranslational protein modification, in which the small protein ubiquitin is covalently attached to substrate proteins. This modification can mark substrates for degradation by the proteasome or lysosomes, or alternatively can alter protein localization, function, trafficking, and protein-protein interactions. Ubiquitylation is a ubiquitous modification, but it is enriched in the brain and often accumulates in neurodegenerative conditions (Fischer et al., 2009). PY - 2020 JO - microPublication Biology ER -