TY  - GEN
T1  - Glutamatergic transmission regulates locomotory behavior on a food patch in C. elegans
AU  - Wolf, Trevor
AU  - Perez, Ariana
AU  - Harris, Gareth
DO  - 10.17912/micropub.biology.000332
UR  - http://beta.micropublication.org/journals/biology/micropub-biology-000332/
AB  - Sensation of environmental cues and decisions made as a result of processing of specific sensory cues underlies a myriad of behavioral responses that control every-day life decisions and ultimately survival in many organisms. Despite the appreciation that organisms can sense, process, and translate sensory cues into a behavioral response, the neural mechanisms and molecules that mediate these behaviors are still unclear. Neurotransmitters, such as glutamate, have been implicated in a variety of sensory-dependent behavioral responses, including olfaction, nociception, mechanosensation, and gustation (Mugnaini et al.., 1984, Wendy et al.., 2013, Daghfous et al.., 2018). Despite understanding the importance of glutamate signaling in sensation and translation of contextual cues on behavior, the molecular mechanisms underlying how glutamatergic transmission influences sensory behavior is not fully understood. The nematode, C. elegans, is able to sense a variety of sensory cues. These types of sensory-dependent behavioral responses are mediated through olfactory, gustatory, mechanosensory and aerotactic circuits of the worm (Lans and Jansen, 2004, Milward et al., 2011, Bretscher et al.., 2011, Kodama-Namba et al.., 2013, Ghosh et al., 2017). Odor guided behavior toward attractants, such as, food cues requires neurotransmitters, that include, glutamate (Chalasani et al.., 2007, Chalasani et al.., 2010). More specifically, once on a food source, wild type N2 hermaphrodites will generally be retained on a food source (Shtonda and Avery, 2006, Milward et al.., 2011, Harris et al.., 2019). The types, quality, pathogenicity, and perception of food can modulate food recognition, food leaving rates, and overall navigational strategies towards food (Zhang et al.., 2005, Shtonda and Avery, 2006; Ollofsson et al.., 2014). These types of behaviors are based on detection of environmental cues, including oxygen, metabolites, pheromones, and odors. Food leaving behaviors have been shown to be influenced by a number of neuronal signals (Shtonda and Avery, 2006, Bendesky et al.., 2011, Ollofsson et al.., 2014, Meisel et al.., 2014, Hao et al.., 2018).
PY  - 2020
JO  - microPublication Biology
ER  -