TY - GEN T1 - The tetraspanin Cd63 is required for eye morphogenesis in Xenopus AU - Kreis, Jennifer AU - Bonß, Ramona AU - Vick, Philipp DO - 10.17912/micropub.biology.000335 UR - http://beta.micropublication.org/journals/biology/micropub-biology-000335/ AB - Tetraspanins (TSPAN) are a family of (33 in humans) scaffold proteins consisting of the name-giving four membrane-spanning domains, two extracellular loops, and an intracellular N- and C-terminus. By forming ‘tetraspanin-enriched microdomains’ they participate in organizing the plasma membrane and serve as multipurpose adapters. Some can be found ubiquitously in most cells, while others are specific to certain cell types. On a subcellular level, enrichment in distinct membrane-associated organelles has been documented for several members (Termini and Gillette, 2017). PY - 2020 JO - microPublication Biology ER -