TY  - GEN
T1  - Depletion of Foxk transcription factors causes genome-wide transcriptional misregulation and developmental arrest in zebrafish embryos
AU  - Geng, Fan-Suo
AU  - de la Calle-Mustienes, Elisa
AU  - Gómez-Skarmeta, José Luis
AU  - Lister, Ryan
AU  - Bogdanovic, Ozren
DO  - 10.17912/micropub.biology.000341
UR  - http://beta.micropublication.org/journals/biology/micropub-biology-000341/
AB  - Foxk proteins are transcription factors from the forkhead box family, implicated in diverse biological processes such as glucose metabolism, inhibition of myogenic differentiation, and repression of autophagy (Bowman et al. 2014; Shi et al. 2012; Sukonina et al. 2019). Recent work has demonstrated that Foxk proteins predominantly act as transcriptional repressors in muscle cells and fibroblasts, where they recruit the Sin3-HDAC complex to silence targeted loci (Bowman et al. 2014). However, Foxk proteins can also associate with the DNA demethylase TET1 in vivo and in vitro (Sun et al. 2016), which is suggestive of their role in transcriptional activation and formation of open chromatin. To date, the majority of Foxk studies have been carried out in cultured cells, with limited information available on in vivo developmental requirements for Foxk function (Sukonina et al. 2019).
PY  - 2020
JO  - microPublication Biology
ER  -