TY  - GEN
T1  - Pyrogallol induces oxidative stress defects in the fission yeast S. pombe
AU  - Ahamad, Nafees
AU  - Anjum, Simmi
AU  - Ahmed, Shakil
DO  - 10.17912/micropub.biology.000348
UR  - http://beta.micropublication.org/journals/biology/micropub-biology-000348/
AB  - Pyrogallol [C6H3 (OH)3] is an organic white water-soluble solid compound that finds several uses. It is used as an ingredient in the hair cosmetic industry (Mazzei et al., 2007), photography (Upadhyay et al., 2010), and as an antipsoriatic drug (Khan et al., 2002). Besides its beneficiary roles in industries and as a consumer product, some previous studies report the toxicity caused by pyrogallol due to its tendency to produce free radicals and trigger apoptosis (Han and Park, 2002). Oxidative stress is mainly the cause of its toxicity and was reported to be carcinogenic and tumorigenic in female and male mice respectively (Mercado et al., 2013). Humans are often exposed to pyrogallol through hair dyes and ingestion of beverages like tea, coffee, and cause deleterious effects if consumed beyond the permissible amount. However, some previous studies also suggest its therapeutic role in inhibiting tumor growth in certain animal models as well as induces G2-M arrest in human lung cancer cells (Yang et al., 2009). Additionally, the protective effect of pyrogallol along with other phenols against the oxidative stress caused due to hydrogen peroxide has been reported in Saccharomyces cerevisiae (Mendes et al., 2015).
PY  - 2021
JO  - microPublication Biology
ER  -