TY  - GEN
T1  - Anti-oxidant MitoQ rescue of AWB chemosensory neuron impairment in a C. elegans model of X-linked Adrenoleukodystrophy
AU  - Guha, Sanjib
AU  - Pujol, Aurora
AU  - Dalfo, Esther
DO  - 10.17912/micropub.biology.000346
UR  - http://beta.micropublication.org/journals/biology/micropub-biology-000346/
AB  - X-linked adrenoleukodystrophy (X-ALD) is a rare neurometabolic disease characterized by inflammatory demyelination in the brain and axonal degeneration in the spinal cord. The disease is caused by mutations in the ATP binding cassette subfamily D member (ABCD1) gene, which encodes the peroxisomal transporter of very long chain fatty acids (VLCFAs) (Ferrer et al., 2010). Accumulation of VLCFAs, increased oxidative stress, and mitochondrial impairment are considered as the main etiological factor of X-ALD and other neurodegenerative disorders as reviewed in Kemp et al., 2016, Turk et al., 2020 and Guha et al., 2020 (a).
PY  - 2021
JO  - microPublication Biology
ER  -