TY  - GEN
T1  - The ISWI chromatin remodelling factor NURF is not required for mitotic male X chromosome organisation
AU  - Kwon, So Yeon
AU  - Jang, Boyun
AU  - Badenhorst, Paul
DO  - 10.17912/micropub.biology.000360
UR  - http://beta.micropublication.org/journals/biology/micropub-biology-000360/
AB  - Drosophila NURF is an ISWI-containing chromatin remodeling complex that catalyzes ATP-dependent nucleosome sliding. By sliding nucleosomes, NURF can alter chromatin dynamics to control both transcription and genome organisation. NURF is composed of four subunits including the catalytic subunit Iswi and a large, highly conserved, NURF-specific scaffold subunit. In Drosophila this large subunit is Nurf301 (also known as Enhancer of bithorax (E(bx)) or CG32346, FlyBase ID:FBgn0000541) in humans bromodomain and PHD finger transcription factor (BPTF)) (Barak et al., 2003; Xiao et al., 2001). Nurf301/BPTF contains domains that have the potential to recognize specific histone modifications including a C-terminal bromodomain that recognizes histone H4 acetylated at lysine position 16 (H4K16Ac) (Kwon et al., 2009; Ruthenberg et al., 2011). H4K16Ac is enriched on the Drosophila male X chromosome as a result of the actions of the male-specific lethal (MSL) complex (reviewed in Samata and Akhtar, 2018) and in addition to being bound by Nurf301 can influence the activity of the Iswi subunit of NURF (Clapier et al., 2001; Corona et al. 2002).
PY  - 2021
JO  - microPublication Biology
ER  -