TY  - GEN
T1  - The S1A protease family members CG10764 and CG4793 regulate cellular immunity in Drosophila
AU  - KR, Pooja
AU  - Lee, Jonathan
AU  - Mortimer, Nathan T
DO  - 10.17912/micropub.biology.000370
UR  - http://beta.micropublication.org/journals/biology/micropub-biology-000370/
AB  - Cellular immune responses are an important aspect of innate host defense against infection and are broadly conserved from insects to mammals. The model organism Drosophila melanogaster uses the cellular encapsulation response to protect against macroparasite infection (Carton et al., 2008; Mortimer, 2013). This response shows genetic conservation with human immune responses (Howell et al., 2012), and may serve as a useful model to better understand human immune cell functions. Drosophila larvae are commonly infected by parasitoid wasps and following infection mount a cellular immune response to kill the parasite. This response is mediated by two cell types, circulating macrophage-like immune cells known as plasmatocytes and infection-induced immune cells called lamellocytes (Honti et al., 2014; Rizki, 1957). Plasmatocytes operate as the first line responders to infection by recognizing and binding to the wasp egg (Mortimer et al., 2012; Russo et al., 1996). This process is then followed by the production of lamellocytes that form a consolidated multi-layered capsule, thereby killing the wasp (Kim-Jo et al., 2019; Russo et al., 1996). Recent findings have begun to elucidate the regulation of the encapsulation response in Drosophila, including a role for the evolutionarily conserved JAK-STAT signaling pathway (Sorrentino et al. 2004; Yang et al. 2015). The roles of JAK-STAT signaling are not completely understood, but the pathway has been linked to the production of lamellocytes (Bausek and Zeidler, 2014; Hanratty and Dearolf, 1993; Luo et al., 1995, 1997; Sorrentino et al., 2004).
PY  - 2021
JO  - microPublication Biology
ER  -