TY  - GEN
T1  - Similar responsiveness between C57BL/6N and C57BL/6J mouse substrains to superovulation
AU  - Shindo, Miyuki
AU  - Tsumura, Hideki
AU  - Miyado, Kenji
AU  - Kang, Woojin
AU  - Kawano, Natsuko
AU  - Yoshida, Tomoko
AU  - Fukami, Maki
AU  - Miyado, Mami
DO  - 10.17912/micropub.biology.000375
UR  - http://beta.micropublication.org/journals/biology/micropub-biology-000375/
AB  - Superovulation refers to the drug-induced release of multiple eggs that is required for in vitro fertilization (IVF), and its high efficiency largely reduces the number of mice used per experiment. Both follicle stimulating hormone (FSH) and pregnant mare’s serum gonadotropin also known as equine chorionic gonadotropin (eCG) stimulate ovarian follicular development and inhibin secretion (Fowler and Edwards 1957). Inhibin has been isolated from ovarian follicular fluid as a substance that selectively inhibits FSH secretion from the pituitary gland (Luisi et al. 2005). Inhibin suppresses ovulation, and its function is neutralized by anti-inhibin serum (AIS) (Takeo and Nakagata 2015). Treatment with AIS plus eCG induced the ovulation of higher number of eggs than eCG alone in C57BL/6J (B6J) mice aged between 3 and 30 weeks, except for 6 weeks of age (Takeo et al. 2019).
PY  - 2021
JO  - microPublication Biology
ER  -