TY  - GEN
T1  - Recombination and biased segregation of mitochondrial genomes during crossing and meiosis of different Schizosaccharomyces pombe strains
AU  - Kamrad, Stephan
AU  - Rodríguez-López, María
AU  - Dey, Shoumit
AU  - Hoti, Mimoza
AU  - Wallace, Henry
AU  - Ralser, Markus
AU  - Bähler, Jürg
DO  - 10.17912/micropub.biology.000390
UR  - http://beta.micropublication.org/journals/biology/micropub-biology-000390/
AB  - Mitochondria are typically inherited from one parent only, which is thought to suppress selfish genetic elements. In organisms with differentiated sexes, mitochondria are usually inherited through the mother (Hoekstra 2000). Due to the larger size of the maternal gamete, paternal mitochondria naturally find themselves at a disadvantage and they are further excluded, sequestered and/or degraded by dedicated mechanisms (Bendich 2013). Yeasts have no sexes in the strict sense as their gametes are of equal size (isogamy), and mating types do not determine mitochondrial transmission. Yet, yeasts have been shown to inherit mitochondrial genomes largely uniparentally. Saccharomyces cerevisiae mitochondria from both parents are mixed during gamete fusion but interactions with the cytoskeleton and bottleneck mechanisms ensure that only a single mitotype persists after a few rounds of mitotic division (Xu and He 2015). A recent paper has elucidated the mechanism through which uniparental inheritance is achieved in the standard laboratory strain of Schizosaccharomyces pombe (Chacko, Mehta, and Ananthanarayanan 2019). Mitochondria are anchored to the cell poles by Mcp5 and stay physically separated during meiosis, ultimately resulting in spores inheriting only those mitochondria anchored on their side of the tetrad. Each parent, therefore, passes on its mitochondria to only two of the four spores.
PY  - 2021
JO  - microPublication Biology
ER  -