TY  - GEN
T1  - Background mutation in strain RB2126 affects the locomotion behavior of flp-1 mutants
AU  - Topalidou, Irini
DO  - 10.17912/micropub.biology.000393
UR  - http://beta.micropublication.org/journals/biology/micropub-biology-000393/
AB  - The FLP family of neuropeptides contains at least 30 genes in C. elegans (Li and Kim, 2008). Some of the flp genes were found to play roles in locomotion, egg laying, and sleep, but most flp genes have unknown function (Li and Kim, 2008; Chang et al. 2015). flp-1 is one of the few flp genes whose mutations are reported to cause overt behavioral defects (Nelson et al. 1998; Hums et al. 2016; Buntschuh et al. 2018; Oranth et al. 2018). The initial flp-1 deletion alleles that were analyzed behaviorally (yn2 and yn4; Nelson et al. 1998) included a deletion of part of daf-10 (Ailion and Thomas, 2003; Buntschuh et al. 2018). This resulted in some of the initial behaviors that were attributed to FLP-1 peptides being caused by loss of daf-10 activity (Buntschuh et al. 2018). Subsequent analysis of newer flp-1 deletion alleles suggests that FLP-1 peptides are involved in nose touch sensitivity, locomotion, and reproduction (Buntschuh et al. 2018).
PY  - 2021
JO  - microPublication Biology
ER  -