TY  - GEN
T1  - The IFT20 homolog in Caenorhabditis elegans is required for ciliogenesis and cilia-mediated behavior
AU  - De-Castro, Ana R. G.
AU  - Quintas-Gonçalves, Joana
AU  - Silva-Ribeiro, Tiago
AU  - Rodrigues, Diogo R. M.
AU  - De-Castro, Maria J. G.
AU  - Abreu, Carla M.
AU  - Dantas, Tiago J.
DO  - 10.17912/micropub.biology.000396
UR  - http://beta.micropublication.org/journals/biology/micropub-biology-000396/
AB  - A high diversity of cilium types have evolved to carry out a multitude of sensorial and motility functions in animals. It is therefore not surprising that defects in cilium structure and function have been associated with various severe multi-organ disorders, commonly known as ciliopathies (Sreekumar and Norris 2019). Regardless of their type, cilium assembly relies on bidirectional motor-driven transport known as intraflagellar transport (IFT; Prevo et al. 2017). Anterograde IFT driven by kinesin-2 transports different cargos in IFT trains along axonemal microtubules from the ciliary base to the tip of the cilium. Upon reaching the tip, these IFT trains are dismounted, rearranged and prepared for transport in the opposite direction back to the ciliary base by the dynein-2 motor complex. IFT trains are composed of at least 16 IFT-B subunits and 6 IFT-A subunits (Prevo et al. 2017). IFT20 is part of the IFT-B complex and has been shown to be of critical importance for ciliogenesis in human and mouse models (Follit et al. 2006; Jonassen et al. 2008; Katoh et al. 2017; Lim et al. 2020).
PY  - 2021
JO  - microPublication Biology
ER  -