TY  - GEN
T1  - Rapid degeneration of Drosophila olfactory neurons in Orco mutant maxillary palps
AU  - Task, Darya
AU  - Potter, Christopher J
DO  - 10.17912/micropub.biology.000398
UR  - http://beta.micropublication.org/journals/biology/micropub-biology-000398/
AB  - The odorant receptor co-receptor Orco forms ligand-gated ion channels with odorant receptors (ORs) tuned to specific odors; Orco is required for trafficking of these complexes to the dendrites of olfactory neurons (Larsson et. al., 2004). Mutation of the Orco gene not only abolishes olfactory neuron activity but has also revealed potential new roles for this gene in the development and maintenance of olfactory systems in a variety of insects. In ants and honeybees, Orco mutation leads to a loss of olfactory sensory neurons in the periphery, as well as severe defects in the morphology of the antennal lobe, the first olfactory processing center in the insect brain (Trible et al., 2017; Yan et al., 2017; Chen et al., 2021). These deficits are likely developmental as they are apparent at adult eclosion. Orco mutant hawkmoth males show more modest losses in antennal lobe volume associated with pheromone-sensing olfactory neurons (Fandino et al., 2019). In contrast, in Anopheles coluzzii and Aedes aegypti mosquitoes Orco mutation does not appear to lead to olfactory neuron loss or gross deficits in antennal lobe anatomy (though the latter has not been examined in depth) (Sun et al., 2020; DeGennaro et al., 2013).
PY  - 2021
JO  - microPublication Biology
ER  -