TY  - GEN
T1  - ifas-1 is upregulated by fungal infection in a GPA-12 and STA-2-independent manner in the Caenorhabditis elegans epidermis
AU  - Omi, Shizue
AU  - Zhang, Xing
AU  - Thakur, Nishant
AU  - Pujol, Nathalie
DO  - 10.17912/micropub.biology.000400
UR  - http://beta.micropublication.org/journals/biology/micropub-biology-000400/
AB  - The natural fungal pathogen Drechmeria coniospora pierces the worm’s cuticle and its hyphae grow throughout the organism. In the epidermis, this triggers a rapid increase in the expression of genes from the nlp (for neuro-peptide-like protein) and cnc (caenacin) families. These genes encode structurally-related antimicrobial peptides (AMPs). We have defined major signalling pathways required for the regulation of nlp‑29 gene expression. Two of them, one specific for infection and the second also activated by wounding, act upstream of a highly conserved p38 MAPK signalling cascade. The induction of cnc‑2 upon infection, on the other hand, is independent of PMK-1/p38 MAPK, but requires DBL-1/TGFß produced by certain neuronal cells, acting via a non-canonical TGFß pathway in epidermal cells. The STAT transcription factor-like protein, STA‑2, is essential for both the PMK-1/p38 MAPK, and DBL-1/TGFß immune signalling pathways, to govern the transcriptional response to fungal infection in the epidermis (reviewed in Kim and Ewbank, 2018; Martineau et al., 2021).
PY  - 2021
JO  - microPublication Biology
ER  -