TY  - GEN
T1  - A Mutation of lips-6 in C. elegans
AU  - Cohen, Sarah M
AU  - Le, Henry H
AU  - Sternberg, Paul W
DO  - 10.17912/micropub.biology.000419
UR  - http://beta.micropublication.org/journals/biology/micropub-biology-000419/
AB  - The efficient CRISPR/Cas9 genome editing toolkit in the nematode Caenorhabditis elegans has made the creation of null mutants easier than ever. The putative lipid hydrolase lips-6 is known to function in the DAF-12/DIN-1 pathway to promote fat mobilization during periods of starvation in adult worms (Tao et al. 2016). Similarly, it was found to be strongly downregulated in response to dauer ascarosides given during the L1 to L2d decision in larval worms (Cohen et al. 2021). Here, we have created a mutant of the putative lipase lips-6 and studied its lifespan as well as its ascaroside profile.
PY  - 2021
JO  - microPublication Biology
ER  -