TY  - GEN
T1  - ATG8 is conserved between Saccharomyces cerevisiae and psychrophilic, polar-collected fungi
AU  - Ivory, Brenna J.
AU  - Smith, Hannah M.
AU  - Cabrera, Elizabeth
AU  - Robinson, Meaghan R.
AU  - Sparks, Jackson T.
AU  - Solem, Amanda
AU  - Ishihara, Jun-ichi
AU  - Takahashi, Hiroki
AU  - Tsuji, Masaharu
AU  - Segarra, Verónica A.
DO  - 10.17912/micropub.biology.000446
UR  - http://beta.micropublication.org/journals/biology/micropub-biology-000446/
AB  - Autophagy is a stress response mechanism through which eukaryotic cells target and sequester unnecessary or damaged cellular components for degradation and recycling. The hallmark of the autophagy process is the formation of a large (600-900 nm in diameter), double-bilayered autophagosome, a temporary vesicle responsible for sequestering and transporting the cellular components to be recycled to the degradative organelle of the cell. The vacuole functions as the degradative organelle in yeast, where the molecular process of autophagy was first characterized. Autophagy is orchestrated by a group of proteins known as AuTophaGy-related or Atg proteins. Depending on the stress stimuli experienced, eukaryotic cells can deploy a number of different forms of autophagy. These include a general form known as macroautophagy that targets cellular components in bulk for degradation, as well as highly specific forms that target highly specific cellular components such as ribosomes (ribophagy), mitochondria (mitophagy), and peroxisomes (pexophagy). A specific set of core Atg protein machinery is shared among all of these forms of autophagy, and is essential for regulating and bringing about the formation of autophagosomes. Atg8p, coded by the ATG8 gene in Saccharomyces cerevisiae, is one of these core Atg proteins that is essential for autophagy in eukaryotes.
PY  - 2021
JO  - microPublication Biology
ER  -