TY  - GEN
T1  - Suppression of him-14(it44ts) by a transgene insertion expressing GFP::COSA-1
AU  - Girard, Chloé
AU  - Akerib, Chantal C
AU  - Villeneuve, Anne M
DO  - 10.17912/micropub.biology.000430
UR  - http://beta.micropublication.org/journals/biology/micropub-biology-000430/
AB  - Formation of crossovers (COs) during meiosis depends on the coordinated activities of multiple pro-CO factors, including the MutSγ complex and COSA-1, that become concentrated at the sites of CO-designated recombination intermediates in an interdependent manner (Yokoo et al. 2012; Woglar and Villeneuve 2018). The MutSγ complex is a heterodimer comprising the conserved proteins MSH-5 and MSH-4 (aka HIM-14, encoded by the him-14 gene) (Zalevsky et al. 1999; Kelly et al. 2000). COSA-1 is a member of the cyclin superfamily and is hypothesized to function as part of a cyclin-dependent protein kinase (CDK) complex (Yokoo et al. 2012). The MutSγ complex was suggested to be a potential target for this hypothesized COSA-1 dependent CDK activity, as MSH-5 has multiple potential CDK phosphorylation sites and can be phosphorylated in vitro by a mammalian CDK. These and other data led to a model in which COSA-1-dependent phosphorylation boosts the activity of MutSγ as part of a positive feedback loop that concentrates pro-CO factors at CO sites (Yokoo et al. 2012).
PY  - 2021
JO  - microPublication Biology
ER  -