TY  - GEN
T1  - Endogenous epitope tagging of a JAK/STAT ligand Unpaired1 in Drosophila
AU  - Takemura, Masahiko
AU  - Lu, Yi-Si
AU  - Nakato, Eriko
AU  - Nakato, Hiroshi
DO  - 10.17912/micropub.biology.000387
UR  - http://beta.micropublication.org/journals/biology/micropub-biology-000387/
AB  - The Janus kinase/signal transducer and activator of transcription (JAK/STAT) signaling pathway is involved in various biological processes, including cell proliferation, differentiation, and apoptosis (Morris et al. 2018). The core components of the JAK/STAT pathway are evolutionarily conserved between humans and flies (Arbouzova and Zeidler 2006). While more than 50 cytokines activate the JAK/STAT pathway in humans, there are only three JAK/STAT ligands in Drosophila (Morris et al. 2018). Unpaired 1 (Upd1), one of the three ligands of the Drosophila JAK/STAT pathway, is involved in many developmental processes, including growth and patterning of the wing disc (Ayala-Camargo et al. 2013; Recasens-Alvarez et al. 2017), stem cell maintenance in the testis (Cuevas and Matunis 2011), and specification of follicular epithelial cell fates in the ovary (McGregor et al. 2002).
PY  - 2021
JO  - microPublication Biology
ER  -