TY  - GEN
T1  - Caenorhabditis Intervention Testing Program: the herbicide diuron does not robustly extend lifespan in nematodes
AU  - Osman, Hadley C
AU  - Sedore, Christine A
AU  - Jackson, E Grace
AU  - Battistoni, Elena T
AU  - Hall, David
AU  - Foulger, Anna
AU  - Lucanic, Mark
AU  - Guo, Max
AU  - Driscoll, Monica
AU  - Phillips, Patrick
AU  - Lithgow, Gordon J
DO  - 10.17912/micropub.biology.000448
UR  - http://beta.micropublication.org/journals/biology/micropub-biology-000448/
AB  - The Caenorhabditis Intervention Testing Program (CITP) is a multi-institutional, National Institute on Aging (NIA)-funded consortium with the goal of identifying compounds that will robustly extend lifespan with reproducible effects across genetically diverse Caenorhabditis species and strains (Lucanic et al., 2017). Compounds are prioritized for testing based on computational prediction for lifespan or healthspan effects (Coleman-Hulbert et al., 2019), predicted or known interactions with documented lifespan-regulating pathways, or previous reports for lifespan or healthspan extension in laboratory animals. In this case, diuron was of interest to CITP based on the report of a positive effect on the lifespan of C. elegans strain TJ1060 (spe-9;fer-15) (Lucanic et al., 2018; personal communication). Diuron (1-(3,4-dichlorophenyl)-3,3-dimethylurea) is an herbicide that inhibits photosynthesis by binding photosystem II (Haynes et al., 2000). Diuron has been previously tested in nematode species for toxicity (Neury-Ormanni et al., 2019) and reproductive effects (Mugova et al., 2018), and in both cases showed detrimental effects at high doses only.
PY  - 2021
JO  - microPublication Biology
ER  -