TY  - GEN
T1  - Age-dependent upregulation of Y RNAs in Caenorhabditis elegans
AU  - Park, Sangsoon
AU  - Sohn, Jooyeon
AU  - Kwon, Sujeong
AU  - Kim, Eun Ji E
AU  - Jung, Yoonji
AU  - Park, Hae-Eun H
AU  - Kim, Sieun S
AU  - Lee, Seung-Jae V
DO  - 10.17912/micropub.biology.000452
UR  - http://beta.micropublication.org/journals/biology/micropub-biology-000452/
AB  - Various non-coding RNAs (ncRNAs) change their levels during aging, and influence lifespan in many species, including Caenorhabditis elegans (Garg and Cohen 2014; He et al. 2018; Kim and Lee 2019, Kim et al. 2021). However, the role of Y RNAs, ncRNAs that regulate DNA replication and RNA quality control (Kowalski and Krude 2015), in aging and lifespan remains unknown. C. elegans genome encodes 19 Y RNA homologs, C. elegans Y RNA (CeY) encoded by yrn-1 and 18 stem-bulge RNAs (sbRNAs), each of which contains a conserved stem-loop structure (Fig. 1A) (Kowalski and Krude 2015). Y RNAs form a Ro60 ribonucleoprotein by binding Ro 60-kDa protein (Ro60), which is conserved from bacteria to human (Sim et al. 2020). ROP-1, the C. elegans Ro60, binds and stabilizes CeY (Van Horn et al. 1995; Labbé et al. 1999). rop-1 mRNA and ROP-1 protein levels increase during aging in C. elegans (Liang et al. 2014; Mansfeld et al. 2015; Angeles-Albores et al. 2017), suggesting the potential aging-regulatory functions of ROP-1 and its associated RNA, CeY. Here, we sought to determine the role of the Y RNA homologs in aging and lifespan.
PY  - 2021
JO  - microPublication Biology
ER  -