TY  - GEN
T1  - Drosophila insulin receptor regulates diabetes-induced mechanical nociceptive hypersensitivity
AU  - Dabbara, Harika
AU  - Schultz, Arielle
AU  - Im, Seol Hee
DO  - 10.17912/micropub.biology.000456
UR  - http://beta.micropublication.org/journals/biology/micropub-biology-000456/
AB  - Diabetes is a group of medical conditions that involve the dysregulation of blood glucose and is typically categorized into two types. Type 1 diabetes is an autoimmune disease that results from the immune system attacking insulin-producing cells in the pancreas, causing hyperglycemia and hypoinsulinemia (American Diabetes Association 2014). Type 2 diabetes is characterized by insulin receptors on the membranes of cells becoming resistant to insulin, leading to hyperglycemia and hyperinsulinemia (Petersen and Shulman 2018). Both types of diabetes can trigger complications called painful diabetic neuropathy (PDN). Patients with PDN suffer from a range of symptoms including numbness and tingling in distal extremities and extreme sensitivity to stimuli, such that the touch of one’s clothing on the skin can be painful (Veves et al. 2008). To improve treatment options for these patients, it is important to develop a genetically tractable model system to dissect the underlying mechanisms and test new therapeutics. Previously, we reported a Drosophila model of diabetes-induced nociceptive hypersensitivity (Im et al. 2018). In that study, we established that diabetes-like conditions and disrupted insulin signaling result in prolonged thermal nociceptive hypersensitivity after tissue injury.
PY  - 2021
JO  - microPublication Biology
ER  -