TY  - GEN
T1  - A mutation in budding yeast BRR6 affecting nuclear envelope insertion of the spindle pole body
AU  - Gardner, Jennifer M
AU  - O'Toole, Eileen
AU  - Jaspersen, Sue L
DO  - 10.17912/micropub.biology.000463
UR  - http://beta.micropublication.org/journals/biology/micropub-biology-000463/
AB  - Nuclei, the defining characteristic of eukaryotic cells, are bound by a double lipid bilayer, referred to as the nuclear envelope (NE). Prior to mitosis, components of the microtubule cytoskeleton including microtubule-organizing centers (known as centrosomes in metazoans and spindle pole bodies (SPBs) in fungi) that are located in the cytoplasm throughout interphase must access replicated sister chromosomes located inside the nucleus to form the bipolar mitotic spindle. In metazoans, the NE breaks down (open mitosis); however, in fungi, SPBs are inserted into the NE and the NE remains intact during mitosis (closed mitosis) (reviewed in (Heath 1980; Makarova and Oliferenko 2016)). How a giant protein complex such as a SPB is inserted into the NE is largely unknown, although in budding yeast SPB insertion into the nuclear membrane is coupled with SPB duplication (Jaspersen 2021; Ruthnick and Schiebel 2018).
PY  - 2021
JO  - microPublication Biology
ER  -