TY  - GEN
T1  - The bHLH-PAS gene hlh-34 is expressed in the AVH, not AVJ interneurons
AU  - Cook, Steven J.
AU  - Vidal, Berta
AU  - Hobert, Oliver
DO  - 10.17912/micropub.biology.000467
UR  - http://beta.micropublication.org/journals/biology/micropub-biology-000467/
AB  - bHLH-PAS transcription factors are a metazoan-specific family of transcription factors with diverse functions within and outside the nervous system (Kewley et al. 2004). Caenorhabditis elegans contains five bHLH-PAS proteins: (1) ahr-1, an ortholog of the aryl hydrocarbon receptor (Powell-Coffman et al. 1998); (2) aha-1, an ortholog of the Aryl Hydrocarbon Receptor Nuclear Translocator (ARNT), which is a common dimerization partner for many, but not all bHLH-PAS genes (Powell-Coffman et al. 1998); (3) hif-1, an ortholog of hypoxia-inducible factor HIF1alpha (Jiang et al. 2001); (4) CKY-1, which orthology prediction tools consider to be an ortholog of NPAS4, even though its bHLH domain is very degenerate (nevertheless, CKY-1 heterodimerizes, like other C. elegans bHLH-PAS proteins, with the common AHA-1 partner protein in yeast 2 hybrid assays (Grove et al. 2009)); (5) hlh-34, which Marvvel (Wang et al. 2019) and Ortholist (Shaye and Greenwald 2011) predict to be an ortholog of both the NPAS1/3 and the SIM1/2 subgroups of bHLH-PAS proteins (Yan et al. 2014). However, HLH-34 contains neither of the domains that are found, in addition to the canonical bHLH and PAS domains, in either vertebrate NPAS (PAS_11 domain) or SIM (SIM_C) proteins. HLH-34 may therefore reflect an ancestral version of both subgroups.
PY  - 2021
JO  - microPublication Biology
ER  -