TY  - GEN
T1  - Motivated displacement assay distinguishes ALA neuron mutants from RIS neuron mutants during recovery from heat stress in Caenorhabditis elegans
AU  - Chávez-Pérez, Carlos
AU  - Jafari, Niusha
AU  - Keenan, Brendan T
AU  - Raizen, David M
AU  - Rohacek, Alex M
DO  - 10.17912/micropub.biology.000468
UR  - http://beta.micropublication.org/journals/biology/micropub-biology-000468/
AB  - Like other animals, the nematode C. elegans exhibits reduced movement and sleep in response to sickness, which can be induced by exposure to high temperatures (Hill et al. 2014; Nelson et al. 2014) ultraviolet light (DeBardeleben et al. 2017), and other stressful exposures (Hill et al. 2014; Goetting et al. 2020). This response has been termed Stress/Sickness-Induced Sleep (SIS) (Hill et al. 2014; Trojanowski and Raizen 2016). Exposure to the stressor leads to quiescence in part via release of the cytokine Epidermal Growth Factor (EGF) (Hill et al. 2014; Konietzka et al. 2020), which is encoded by the gene lin-3 (Hill and Sternberg 1992). EGF activates the ALA and RIS neurons, which then release their respective neuropeptides to effect reduced movement and behavioral quiescence (Konietzka et al. 2020).
PY  - 2021
JO  - microPublication Biology
ER  -