TY  - GEN
T1  - The Argonaute Proteins ALG-1 and ALG-2 Are Linked to Stress Resistance and Proteostasis
AU  - Finger, Fabian
AU  - Ottens, Franziska
AU  - Hoppe, Thorsten
DO  - 10.17912/micropub.biology.000457
UR  - http://beta.micropublication.org/journals/biology/micropub-biology-000457/
AB  - A fundamental challenge during the life of an organism is to maintain a functional proteome that can adapt to physiological and environmental stresses. Diverse pathways, collectively termed the protein homeostasis (proteostasis) network (PN), provide protein quality control (Roth and Balch 2011; Morimoto and Cuervo 2014). The PN is highly dynamic and continuously adjusted to changing physiological demands. Proteostasis decline results in increased susceptibility to environmental stress and shortened lifespan (Heider et al. 2007; Labbadia and Morimoto 2015). Rapid activation of specific stress response pathways, including the heat shock response (HSR), the unfolded protein response in the endoplasmic reticulum (ER) (UPRER) and in mitochondria (UPRmt), and the oxidative stress response prevent cellular damage or accumulation of misfolded proteins (Labbadia and Morimoto 2015). However, physiological and environmental changes challenge these stress response mechanisms and trigger increased degradation of damaged proteins. Maintaining the PN depends on changes in gene expression to regulate the protein folding and degradation capacities of the organism. The class of short non-conding microRNAs can bind with partial complementarity to target mRNAs facilitating either mRNA degradation or translational decay (Filipowicz et al. 2008). Previous findings showed that microRNAs and the RNAi machinery regulate diverse mechanisms important for development, aging, and stress signaling as well as the development of neurological disorders like myotonic dystrophy type 1 (Alvarez-Garcia and Miska 2005; Smith-Vikos and Slack 2012; Qawasmi et al. 2019). We described a role for microRNAs in environmental perception and organismal adaption and identified mir-71 as a key player in translating sensory inputs from olfactory food cues to the PN in the nematode Caenorhabditis elegans (Finger et al. 2019). However, the general role of microRNA processing in proteostasis regulation remains unclear.
PY  - 2021
JO  - microPublication Biology
ER  -