TY  - GEN
T1  - Phase separation dynamics of the C. elegans PGL-1 P granule protein in oocytes are sensitive to heat stress
AU  - Watkins, Brooklynne
AU  - Schisa, Jennifer A.
DO  - 10.17912/micropub.biology.000476
UR  - http://beta.micropublication.org/journals/biology/micropub-biology-000476/
AB  - ­In many cell types, subsets of RNA binding proteins adopt a default de-mixed state, condensing into ribonucleoprotein (RNP) granules (Alberti and Carra, 2018). In the C. elegans germ line PGL-1, an RGG domain protein, is condensed into P granules. P granules associate closely with nuclear pores of pachytene nuclei in the adult germ line but detach from nuclei as oocytes develop (Strome and Wood, 1982; Pitt et al., 2000) and contribute to maternal mRNA regulation (Voronina, 2013). In contrast, other RNA binding proteins have a default mixed, or decondensed, state in the adult germ line. For example, the KH domain protein MEX-3 is largely diffuse throughout the cytosol of oocytes and condenses into P granules in early embryos (Draper et al., 1996).
PY  - 2021
JO  - microPublication Biology
ER  -