TY  - GEN
T1  - High confidence ATFS-1 target genes for quantifying activation of the mitochondrial unfolded protein response
AU  - Soo, Sonja K
AU  - Van Raamsdonk, Jeremy M
DO  - 10.17912/micropub.biology.000484
UR  - http://beta.micropublication.org/journals/biology/micropub-biology-000484/
AB  - The mitochondrial unfolded protein response (mitoUPR) is a stress response pathway that promotes cell survival and restores mitochondrial function when mitochondrial health is compromised (Haynes et al. 2013; Jovaisaite et al. 2014; Shpilka and Haynes 2018). While a mitoUPR was first reported in mammalian cells (Zhao et al. 2002), the initial work on the mitoUPR in C. elegans was performed by Yoneda et al. who found that treatment with ethidium bromide, which affects the replication and expression of mitochondrial DNA, increased the expression of the mitochondrial chaperone gene hsp-6 (Yoneda et al. 2004). Based on this observation, they generated hsp-6p::gfp and hsp-60p::gfp reporter strains to further study the mitoUPR. They found that either RNA interference (RNAi) targeting spg-7, the worm homolog of paraplegin, or RNAi targeting other genes encoding mitochondrial proteins resulted in activation of the hsp-6p::gfp and hsp-60p::gfp reporter strains (Yoneda et al. 2004).
PY  - 2021
JO  - microPublication Biology
ER  -