TY  - GEN
T1  - Changes in Histone H3 Acetylation on Lysine 9 Accompany Aβ 1-40 Overexpression in an Alzheimer’s Disease Yeast Model
AU  - Hugais, Muna M.
AU  - Cobos, Samantha N.
AU  - Bennett, Seth A.
AU  - Paredes, Jailene
AU  - Foran, Genevieve
AU  - Torrente, Mariana P.
DO  - 10.17912/micropub.biology.000492
UR  - http://beta.micropublication.org/journals/biology/micropub-biology-000492/
AB  - Alzheimer’s Disease (AD) is a progressive and incurable neurodegenerative disease. The disease results in the gradual degeneration and eventual death of neurons causing complications with movement and mental function (Gao and Hong 2008). AD is characterized by plaques of amyloid-beta (Aβ) peptides in the cerebral cortex of the brain. Aβ peptides range from 37 to 49 amino acid residues in length (Chen et al. 2017). Aβ 1-40 and Aβ 1-42 are the most common species in the cerebral cortex of AD patient samples, with Aβ 1-40 being the most abundant (Seynnaeve et al. 2018; Spies et al. 2010). Aβ accumulation and aggregation are thought to lead to a series of neurodegenerative events (Novo et al. 2018). However, the factors triggering the aggregation of Aβ proteins have not been completely characterized. Furthermore, exactly how Aβ aggregation leads to neurodegeneration remains unclear (Wolfe and Cyr 2011).
PY  - 2021
JO  - microPublication Biology
ER  -