TY  - GEN
T1  - Validation of differential DNA methylation in newborns exposed to tobacco smoke during gestation using bisulfite pyrosequencing
AU  - Crute, Christine
AU  - Liao, Yihan
AU  - Son, Esther
AU  - Grenier, Carole
AU  - Huang, Zhiqing
AU  - Hoyo, Cathrine
AU  - Murphy, Susan K.
DO  - 10.17912/micropub.biology.000509
UR  - http://beta.micropublication.org/journals/biology/micropub-biology-000509/
AB  - The Developmental Origins of Health and Disease (DOHaD) hypothesis is based on anecdotal and empirical findings that early life exposures are associated with later life susceptibility to disorders and diseases (Barker 1990). Our susceptibility to in utero toxicant exposures is now a major focal point in public health research. Gestational exposure to tobacco smoke is associated with low birth weight (Sbrana et al. 2011), airway hyperreactivity associated with asthma (Lee et al. 2015), and neurodevelopmental effects such as attention deficit hyperactivity disorder (Nomura et al. 2010; Sciberras et al.2011). These outcomes have been linked to epigenetic alterations, including changes in DNA methylation (Suter et al. 2013; Markunas et al. 2014; Richmond et al. 2015).
PY  - 2022
JO  - microPublication Biology
ER  -