TY  - GEN
T1  - The ClC Cl– channel CLH-1 mediates HCO3– efflux from the amphid sheath glia in C. elegans
AU  - Fernandez-Abascal, Jesus
AU  - Bianchi, Laura
DO  - 10.17912/micropub.biology.000510
UR  - http://beta.micropublication.org/journals/biology/micropub-biology-000510/
AB  - Cellular function is regulated by both intracellular and extracellular pH. Proton and bicarbonate transporters and exchangers, as well as ion channels permeable to protons and bicarbonate (HCO3–) participate to pH regulation (Chesler, 2003). Importantly, channels and transporters that regulate extracellular pH have the potential of influencing the function of nearby cells, making them particularly critical for the function of a tissue or organ as a whole. Extracellular pH regulation, and in particular buffering of extracellular acid loads, is especially important in the nervous system where high neuronal activity leads to the production and release in the extracellular space of a significant amount of acid.
PY  - 2022
JO  - microPublication Biology
ER  -