TY  - GEN
T1  - Ubiquitous Knockdown of Mettl3 using TRiP.GL01126 Results in Spermatid Mislocalization During Drosophila Spermatogenesis
AU  - Rowe, Lauren
AU  - Rockwell, Antonio L
DO  - 10.17912/micropub.biology.000511
UR  - http://beta.micropublication.org/journals/biology/micropub-biology-000511/
AB  - METTL3 contains the catalytic subunit of the m6A methyltransferase complex. METTL3 serves as a “writer” protein during mRNA processing as it methylates nitrogen at the sixth position of adenosine residues in eukaryotic organisms (Rottman et al., 1994). Mettl3 and its homologs have been shown to be crucial for developmental events in eukaryotic organisms (Hsu et al., 2017). Developmental processes such as gametogenesis depend on the proper functioning of METTL3. Previous research in Drosophila spermatogenesis suggests that somatic cyst cell specific knockdown of Mettl3 leads to misregulation of an essential protein profilin (chic), which disrupts the somatic permeability barrier (Rockwell and Hongay, 2020). Using spermatogenesis as a model system, our research uses ubiquitous knockdowns to further elucidate the role of METTL3 in spermatogenesis.
PY  - 2022
JO  - microPublication Biology
ER  -