TY  - GEN
T1  - UNC-33L partially rescues life span and locomotion defects in unc-33 mutants but fails to rescue dauer formation defects.
AU  - Lopez, Melissa E
AU  - Vacio, Arianna M
AU  - Cantu, Jason
AU  - Holgado, Andrea
DO  - 10.17912/micropub.biology.000515
UR  - http://beta.micropublication.org/journals/biology/micropub-biology-000515/
AB  - C. elegans have a short life cycle that consists of a larva molting into a reproducing adult by passing through 4 larval stages (L1, L2, L3, and L4). Under favorable conditions, the nematode will go through all 4 larval stages (Wolkow and Hall 2015). On the other hand, if conditions become unfavorable, the nematode will shift into dauer formation right after the L2 phase (L2d). During this alternative life cycle, C. elegans become stress-resistant, developmentally arrested, and long-lived (Albert and Riddle 1983). In addition, they undergo morphological remodeling that allows them to adapt to harsh conditions (Cassandra and Russell 1975). Dauers develop a thickened cuticle, undergo body constriction, and cell compaction. The thickened cuticle inhibits environmental toxins, such as detergent from affecting internal organs (Wolkow and Hall 2015). Once conditions become favorable, the nematode will exit out of the dauer phase and continue on to become a reproducing adult.
PY  - 2022
JO  - microPublication Biology
ER  -