TY  - GEN
T1  - Genetic diversity estimates for the Caenorhabditis Intervention Testing Program screening panel
AU  - Teterina, Anastasia A
AU  - Coleman-Hulbert, Anna L
AU  - Banse, Stephen A
AU  - Willis, John H
AU  - Perez, Viviana I
AU  - Lithgow, Gordon J
AU  - Driscoll, Monica
AU  - Phillips, Patrick C
DO  - 10.17912/micropub.biology.000518
UR  - http://beta.micropublication.org/journals/biology/micropub-biology-000518/
AB  - Model organisms have been fruitful tools for elucidating core biological principles. The power of model organism study, in part, is due to the ability to grow large populations with known genetic makeup. One of the most widely adopted genetic models is the hermaphroditic nematode Caenorhabditis elegans. The reproductive style of C. elegans makes it particularly easy to generate and maintain large populations of genetically identical individuals. In fact, the control over genetic variability helped make C. elegans the first multi-cellular organism to have its entire genome sequenced (C. elegans Sequencing Consortium 1998). Despite the success garnered using genetically homogeneous populations, it has become increasingly apparent that many of the phenotypes of interest for study are dependent on genetic background (see Evans et al. 2021 for review). Examples of these background-influenced phenotypes range from α-synuclein toxicity (Wang et al. 2019), to behavioral responses to temperature (Stegeman et al. 2013), dietary influence on lifespan and reproduction (Stastna et al. 2015), and pharmacological efficacy (Lucanic et al. 2017). The dependence on genetic background suggests that attempts to identify core biological systems and functionality could benefit from assaying across genetic diversity to identify genetic background-independent phenotypes. One way to achieve this is to use a panel of populations with intra-population homogeneity and inter-population diversity.
PY  - 2022
JO  - microPublication Biology
ER  -