TY  - GEN
T1  - Visualization of a curated Oryza sativa L. CDPKs Protein-Protein Interaction Network (CDPK-OsPPIN)
AU  - Marques, Joana
AU  - Matiolli, Cleverson C.
AU  - Abreu, Isabel A.
DO  - 10.17912/micropub.biology.000513
UR  - http://beta.micropublication.org/journals/biology/micropub-biology-000513/
AB  - Calcium-Dependent Protein Kinases (CDPKs) are essential translators of calcium ion (Ca2+) signaling in protists (Zhang and Choi, 2001), green algae (Valmonte et al., 2014), and plants (Harmon et al., 1987; Roberts, 1993). The ion Ca2+ is a key second messenger of diverse signaling pathways conveying environmental and developmental cues (Dodd et al., 2010). External and internal signals trigger transient changes of cytosolic Ca2+ ([Ca2+]cyt) levels. These changes in [Ca2+]cyt levels can be perceived by Ca2+ binding proteins, such as Calmodulins (CaMs), Calmodulin-Like proteins (CMLs), Calcineurin B-Like proteins (CBLs), and CDPKs (Dodd et al., 2010). The perception of Ca2+ causes conformational changes in CaMs, CBLs, and CDPKs that allow specific protein-protein interactions. After Ca2+-induced conformational changes, CaMs interact with target proteins and recruit Calmodulin-dependent Protein Kinases (CaMKs) to phosphorylate the CaM targets (Zhang and Lu, 2003). Interestingly, CDPKs were proposed to result from a gene fusion between CaM and CaMKs genes (Zhang and Choi, 2001). Consequently, CDPKs are unique in their ability to sense and decode Ca2+ signals by directly phosphorylating specific targets.
PY  - 2022
JO  - microPublication Biology
ER  -