TY  - GEN
T1  - linc-20 and linc-9 do not have compensatory fertility roles in C. elegans
AU  - Rappaport, Yisrael
AU  - Falk, Roni
AU  - Achache, Hanna
AU  - Tzur, Yonatan B.
DO  - 10.17912/micropub.biology.000524
UR  - http://beta.micropublication.org/journals/biology/micropub-biology-000524/
AB  - Long non-coding RNAs (lncRNAs) are transcripts which are longer than 200 nucleotides which are not translated into proteins. These transcripts are usually transcribed by RNA Polymerase II, often capped, polyadenylated, and spliced (reviewed in (Blythe et al., 2016; Deniz and Erman, 2017; Fatica and Bozzoni, 2014; Fico et al., 2019; Kopp and Mendell, 2018; Marques and Ponting, 2014; Melissari and Grote, 2016; Shields et al., 2019; Ulitsky and Bartel, 2013)). Long intergenic non-coding RNAs (lincRNAs) are a subclass of lncRNAs which are transcribed from genomic regions which do not code for proteins (Deniz and Erman, 2017). Many lincRNAs are transcribed during gametogenesis, and mammalian testis is the tissue with the highest number of dynamically expressed long non-coding RNAs (Soumillon et al., 2013; Washietl et al., 2014). In many metazoans reverse genetics analysis indicated that knockout or knockdown of lncRNAs which are dynamically expressed in reproductive organs did not lead to loss of fertility (Dai et al., 2019; Ganesh et al., 2020; Goudarzi et al., 2019; Li et al., 2020; Wei et al., 2019 Ishtayeh, 2021 #8555; Zhang et al., 2012; Zhou et al., 2021; Zhu et al., 2020). Several reports suggested this is due to redundancy in the action of two or more lncRNA genes (Goudarzi et al., 2019; Ishtayeh et al., 2021; Wichman et al., 2017). To the best of our knowledge testing this hypothesis has not been published.
PY  - 2022
JO  - microPublication Biology
ER  -