TY  - GEN
T1  - ATFS-1 plays no repressive role in the regulation of epidermal immune response
AU  - Martineau, Celine N
AU  - Maynard, Claire A
AU  - Pujol, Nathalie
DO  - 10.17912/micropub.biology.000525
UR  - http://beta.micropublication.org/journals/biology/micropub-biology-000525/
AB  - Drechmeria coniospora is a natural fungal pathogen of Caenorhabditis elegans. Fungal spores are able to pierce the cuticle of the worm, leading to hyphal growth in the entire organism. C. elegans counters the infection by triggering a rapid innate immune response. A hallmark of the response is the secretion of antimicrobial peptides (AMP) encoded by the cnc (caenacin) family and certain nlp (neuro-peptide-like protein) genes (Dierking et al., 2011; Taffoni et al., 2020). We previously showed that impairing mitochondrial function and inducing the mitochondrial unfolded protein response (UPRmt), blocks the expression of AMP genes after infection by D. coniospora, possibly through cross-tissue signaling between the intestine and the epidermis (Zugasti et al., 2016; Ewbank & Pujol, 2016). The molecular pathways involved, however, remain unknown.
PY  - 2022
JO  - microPublication Biology
ER  -