TY  - GEN
T1  - Nuclear localization of a C. elegans CCCH-type zinc finger protein encoded by T26A8.4
AU  - Koyama, Takashi
AU  - Ushida, Chisato
DO  - 10.17912/YHG7-JE66
UR  - http://beta.micropublication.org/journals/biology/yhg7-je66/
AB  - T26A8.4 encodes a CCCH-type zinc finger protein. The amino acid sequence of this protein is partially similar to that of S. cerevisiae Caf120p, which has no zinc finger domain. T26A8.4-encoded RNA was detected more abundantly in germ cells than in other tissues of L4-adult worms according to the NEXTDB data. When expressed specifically in the germline under control of the mex-5 promoter, the T26A8.4-encoded protein localized to germ cell nuclei in the adult hermaphrodite and can be seen in foci (arrowheads in the insets of panels A and C). During germline development, gene expression is primarily regulated posttranscriptionally by the mRNA stability and/or translation with the 3’UTRs (Merritt et al. 2008). To test the post-transcriptional regulation of T26A8.4 expression, T26A8.4::GFP with its own 3’UTR and that with tbb-2 3’UTR were compared. The results showed that T26A8.4 is expressed throughout the germline with both 3’UTRs, indicating that T26A8.4 does not appear to be post-transcriptionally regulated by its 3’UTR.
PY  - 2018
JO  - microPublication Biology
ER  -