TY  - GEN
T1  - Loss of eif-2alpha phosphorylation on S49 (mammalian S51) associated with the integrated stress response hastens development in C. elegans​
AU  - Rollins, Jarod
AU  - Lind, Noah
AU  - Rogers, Aric N.
DO  - 10.17912/W2BM1S
UR  - http://beta.micropublication.org/journals/biology/w2bm1s/
AB  - The gene eif-2alpha (Y37E3.10) in C. elegans encodes for the alpha subunit of eukaryotic translation initiation factor 2 (eIF2). The eIF2 trimer is required for delivering charged tRNAMet to the ribosome in a reaction requiring the hydrolysis of GTP to GDP (Sokabe et al., 2012). The phosphorylation of eif2-alpha on its 49th serine residue (Nukazuka et al., 2008) prevents replenishing GDP with GTP and thus reduces translation initiation by preventing delivery of tRNAMet.  The phosphorylation of the mammalian ortholog of eif-2alpha occurs on serine 51 in response to a variety of stresses (Taniuchi et al., 2016) including: osmotic stress, ultraviolet light, cold shock, oxidative stress, heat shock, anoxia, and serum starvation.
PY  - 2017
JO  - microPublication Biology
ER  -