TY  - GEN
T1  - daf-2 modulates regeneration of mechanosensory neurons I
AU  - Abay, Zehra C.
AU  - Wong, Michelle Yu-Ying
AU  - Neumann, Brent
DO  - 10.17912/W2XD3R
UR  - http://beta.micropublication.org/journals/biology/w2xd3r/
AB  - Caenorhabditis elegans (C. elegans) possess the ability to spontaneously regenerate injured axons via a highly efficient mechanism known as axonal fusion (Ghosh-Roy, et al., 2010; Neumann et al., 2011; Neumann et al., 2015; Abay et al., 2017). Following laser axotomy, regrowth from the proximal axon segment (still attached to the cell body) reconnects and fuses with its separated distal segment (Fig. 1A). We recently demonstrated that the level of axonal fusion increases with age (Abay et al., 2017). The daf-2 gene encodes an insulin-like growth factor/IGF-1 receptor that has previously been shown to inhibits neurite regeneration in an age-dependent fashion (Bryne et al., 2014; Kravtsov et al., 2017). To determine if DAF-2 functions in a similar fashion in the mechanosensory neurons to mediate the age-dependent modulation of axonal regrowth and axonal fusion, we studied axonal regeneration in the posterior lateral microtubule (PLM) neurons of animals carrying the daf-2(e1370) mutation.
PY  - 2017
JO  - microPublication Biology
ER  -