TY  - GEN
T1  - A novel null allele of C. elegans gene ceh-14
AU  - Bayer, Emily
AU  - Hobert, Oliver
DO  - 10.17912/g434-3d85
UR  - http://beta.micropublication.org/journals/biology/g434-3d85/
AB  - We have generated a novel null allele, ot900, of the C. elegans LIM homeodomain gene ceh-14. All existing deletion alleles of ceh-14 were generated using a Tc1 transposon insertion, one of which, ch3, is a putative null based on the resulting frame-shift and a reduction in detectable mRNA and protein levels (Cassata et al. 2000). However, in our hands we have noticed a propensity of the ch3 allele to revert to wild-type after several generations, perhaps due to a more complex rearrangement of the locus caused by the Tc1 transposon than previously appreciated.
PY  - 2018
JO  - microPublication Biology
ER  -