TY  - GEN
T1  - daf-2 regeneration of mechanosensory neurons: integration
AU  - Abay, Zehra C
AU  - Wong, Michelle Yu-Ying
AU  - Neumann, Brent
DO  - 10.17912/W2NW9C
UR  - http://beta.micropublication.org/journals/biology/w2nw9c/
AB  - Caenorhabditis elegans (C. elegans) possess the ability to spontaneously regenerate injured axons via a highly efficient mechanism known as axonal fusion. Following laser axotomy, regrowth from the proximal axon segment (still attached to the cell body) reconnects and fuses with its separated distal segment (Fig. 1). Axonal fusion restores neuronal structure and function (Ghosh-Roy et al., 2010; Neumann et al., 2011; Neumann et al., 2015; Abay et al., 2017). It has been well-established across many different species that advancing age reduces an animals’ capacity for repair after nervous system injury. Although C. elegans display a similar decline in terms of the length of axonal regrowth with advancing age, we recently demonstrated that the propensity to repair the mechanosensory neurons via axonal fusion increases with age (Abay et al., 2017a). This increased level of axonal fusion resulted from more robust exposure of injury-induced phosphatidylserine (PS) ‘save-me’ signals that mediate the reconnection, as well as increased regenerative branching, and reduced retraction and degeneration in the separate axon segment.
PY  - 2017
JO  - microPublication Biology
ER  -