TY  - GEN
T1  - Application of the red-shifted channel rhodopsin Chrimson for the Caenorhabditis elegans cGAL bipartite system
AU  - Cao, Mengyi
AU  - Chai, Cynthia
AU  - Liu, Jonathan
AU  - Sternberg, Paul W
DO  - 10.17912/2JGW-FJ52
UR  - http://beta.micropublication.org/journals/biology/2jgw-fj52/
AB  - Channelrhodopsins are light-gated ion channels that serve as photoreceptors in photosynthetic microbes and have been applied as crucial optogenetic tools in genetic model organisms. When expressed in animals, they enable light-inducible control of ionic membrane permeability, which directly manipulates the activity of neurons expressing the protein. The application of channelrhodopsin-based optogenetics is particularly powerful when used in conjugation with the cGAL (GAL4-UAS) bipartite system (Wang et al., 2017). The mating of neuron-specific GAL4 driver lines to new channelrhodopsin effector lines could expand the genetic toolkit to perturb and manipulate neural circuits in the organism.
PY  - 2018
JO  - microPublication Biology
ER  -